Cellular Process
Statins inhibit endogenous cholesterol production by competitive inhibition of HMG-CoA reductase (HMGCR), the enzyme that catalyzes conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol synthesis. This pathway delineates genes involved in statin pharmacogenomics, including genes involved in mediating the effects of statins on plasma lipoprotein metabolism. 

Sources: [https://www.pharmgkb.org/pathway/PA2031 PharmGKB] and [http://en.wikipedia.org/wiki/Statin Wikipedia]

Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP430 CPTAC Assay Portal].

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[-:-]	Unknown gpml interaction type: mim-translocation
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[-:-]	Unknown gpml interaction type: mim-translocation
[-:-]	Unknown gpml interaction type: mim-translocation
[-:-]	Unknown gpml interaction type: mim-translocation
[LINE:id90b15276]	Invalid interaction type.
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[UnknownPositiveInfluenceReaction:ide4c980d3]	Reaction should contain only one reactant and one product.
[UnknownPositiveInfluenceReaction:idba67fe43]	Reaction should contain only one reactant and one product.