Ether lipid biosynthesis in humans.

Ether lipids (e.g. plasmalogens), are peroxisome-derived glycerophospholipids where the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond (single bond between carbon and oxygen atom). Ether lipids are used to form non-lamellar inverted hexagonal structures in model membranes (indicating they could facilitate membrane fusion processes). Lipid raft microdomains (cholesterol-rich membrane regions involved in cellular signaling) rely on ether lipids for their organization and stability. [PMID:28523433].

The pathway knowledge depicted in this model stems from Robert C. Murphy, who endorsed version r123734.

Metabolic conversion missing an identifier from Rhea have been visualized with double line thickness.

[-:-]	Unknown gpml interaction type: mim-translocation
[-:-]	Unknown gpml interaction type: mim-translocation
[-:-]	Unknown gpml interaction type: mim-translocation
[LINE:id3d7742d1]	Invalid interaction type.
[LINE:bf12c]	Invalid interaction type.
[LINE:id547c9825]	Invalid interaction type.
[LINE:id89f85d64]	Invalid interaction type.
[LINE:d2247]	Invalid interaction type.
[ARROW:a2d38]	Invalid interaction type "ARROW" as an output from reaction.
[ARROW:id5e855469]	Invalid interaction type "ARROW" as an output from reaction.
[ARROW:c05fb]	Invalid interaction type "ARROW" as an output from reaction.
[ARROW:f13fc]	Invalid interaction type "ARROW" as an output from reaction.
[ARROW:fade0]	Invalid interaction type "ARROW" as an output from reaction.
[Label:b12d0]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:b81a0]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:daffe]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:ccfff]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:c65d7]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:b22a6]	 Label cannot be part of reaction. Tranforming to Unknown
[Label:da0aa]	 Label cannot be part of reaction. Tranforming to Unknown
[  
  Peroxisome:f2cf6]	 Shape can not be part of reaction. Tranforming to Unknown
[-:-]	Miriam data (PUBMED: 28523433) for id547c9825 already exists. Ignoring...